I’ve always been wary of overconsuming fat-soluble vitamins (ADEK). Seeing strong medical consensus that 6000IU/day of Vitamin D is safe and even desirable gives me confidence to supplement more liberally.
I've been taking 6000-8000 IU of vitamin D daily along with K2, with no issues. I recommend using drops instead of pills as they allow for more flexible dosing. They aren't more expensive either (in my experience, they're actually cheaper).
I've been taking 10000 IU per day for a year. I mentioned that to my primary care doctor. When I got home and read my health summary, I saw that he wrote "Vitamin D abuse" as one of his concerns.
Interesting. I live at the 45th parallel, and try to get out into the sun everyday during the warmer months, with 5000IU orally per day during the gloomy part of the year. Now I'm wondering if I should get my levels checked.
I'm conflicted.
It seems like in Canada the recommendation was that there was no actual error and the dosage of 1000 IU is still considered good.
It's hard to find more than 2500 IU.
Yeah but to get a prescription you probably have to have a valid reason. If the general directive is that 1000 is fine, I'm assuming it's not easy to get a prescription for that
Meanwhile, my daily 5000IU Vitamin D pills were recalled by some authority in Finland for “excessive dose”, and since it appears that a recall anywhere in the EU will apply to the whole EU, I was given a refund and presumably won’t be able to buy it again.
I recall reading some research which indicated that daily dosage resulted in slightly better protections against cancer. Though better than not taking it at all.
I just got more 5000IU at Walmart which was a nice surprise. Normally I take two 2000IU tablets.
When you buy from reliable brands with a wide range of supplements in their own store on Amazon, you get what that store offers on Amazon as well as elsewhere. If you don't know the brand, Amazon is a bad place to learn about them.
TLDR
Unfortunately, medicine took a very long time to realize that vitamin D is not simply a vitamin that prevents rickets.
We know today that vitamin D is a powerful nuclear receptor-activating hormone of critical importance, especially to the immune system.
With the available data mentioned above, the proposed doses would probably suffice to maintain vitamin D levels around or over 75-100 nmol/L, with practically zero risk of toxicity.
This article is not technical and is 4 pages and includes a 1 paragraph executive summary. There's only 2 pages of content.
There's no specific info about any experiment. It just claims a statistics error was recently found in another paper/experiment. It claims fixing the error suggests we should supplement more Vitamin D.
It gestures vaguely at "Diabetes" and "immune health" and "we used to eat fish" to claim that we want/need more blood Vitamin D. It also points to some other actual studies that might have good evidence that we want or need more Vitamin D.
I would doubt anything in this could cause harm. Vitamin D is fat soluble so taking too much can be dangerous, but I don't think the recommended doses here are close to that dosage.
This paper aims for slightly more than 100nmol/l Vitamin D marker in blood, while other NIH papers claim >375nmol/l is getting into Vitamin D toxicity territory.
NIH previously claimed a serum level of less than 72nmol/l is a health problem, so this paper is bumping that up slightly.
My understanding is that large scale tests of Vitamin D supplementation don't ever seem to turn out as great as all these papers would imply. Maybe their experiments had too low a dose.
My own supplementation has done jack and shit. Maybe I needed a higher dose.
I still hold skepticism that all of humanity needs a supplement, as that's just a sales pitch from a company at that point, but the "Everyone really does need a shitload of Vitamin D supplement" hypothesis at least has a mechanism that makes sense.
Do we need to be skeptical of NIH because of Trump? or they're still okay?
Also, remember - don't take D on its own. Always with magnesium, or you get harmed by it, for all that it also does you good. Body is not built for raw D.
Also also remember, D2 is a vitamin, D3 is a hormone.
If you're looking to build and maintain healthy vitamin D levels, D3 is generally the better supplement choice, according to health experts and studies. Consult your doctor to determine your needs and the best form for you, especially if you have a deficiency or dietary restrictions. -Google Gemini
I think it's important to clarify understandings for non-scientific/med community each time these types of technical discussions occur.
To be clear, NIH hosts an online database called PubMed that contains almost all published biomedical literature. If the article is open access, then it also hosts a copy of the article on PubMed Central.
I mean, I agree MAHA sucks, and Kennedy is a fool and and loser, but the PDF is only hosted at the NIH. It was published in a journal owned by the Korean Society for Preventive Medicine, and the researcher is from Attikon University Hospital, University of Athens School of Medicine, Athens, Greece. And it was published WAAAAAAAY back in 2017.
I’ve always been wary of overconsuming fat-soluble vitamins (ADEK). Seeing strong medical consensus that 6000IU/day of Vitamin D is safe and even desirable gives me confidence to supplement more liberally.
I've been taking 6000-8000 IU of vitamin D daily along with K2, with no issues. I recommend using drops instead of pills as they allow for more flexible dosing. They aren't more expensive either (in my experience, they're actually cheaper).
I've been taking 10000 IU per day for a year. I mentioned that to my primary care doctor. When I got home and read my health summary, I saw that he wrote "Vitamin D abuse" as one of his concerns.
My local grocery store offered free blood testing for Vitamin D a few years ago, and I was low.
I take a 2000IU tablet a few times a week now.
Haha the article states that the recommended daily dose should be 6-8k
Interesting. I live at the 45th parallel, and try to get out into the sun everyday during the warmer months, with 5000IU orally per day during the gloomy part of the year. Now I'm wondering if I should get my levels checked.
I'm conflicted. It seems like in Canada the recommendation was that there was no actual error and the dosage of 1000 IU is still considered good. It's hard to find more than 2500 IU.
I have no idea what to follow at this point
You can get 10,000 or even 100,000 IU tablets prescribed in Canada
Yeah but to get a prescription you probably have to have a valid reason. If the general directive is that 1000 is fine, I'm assuming it's not easy to get a prescription for that
Meanwhile, my daily 5000IU Vitamin D pills were recalled by some authority in Finland for “excessive dose”, and since it appears that a recall anywhere in the EU will apply to the whole EU, I was given a refund and presumably won’t be able to buy it again.
5kIU = 125 micrograms, that's a lot.
The linked paper recommends 8000 IU/day for adults.
I doubt it has 100% bioavailability. Anyway, I don’t trust the low “recommended” amounts.
In the US, you can get 50000 IU on Amazon, good enough for weekly supplementation if you're low (same as prescription strength).
I recall reading some research which indicated that daily dosage resulted in slightly better protections against cancer. Though better than not taking it at all.
I just got more 5000IU at Walmart which was a nice surprise. Normally I take two 2000IU tablets.
The amount of fraud and fakes on amazon is surreal. I wouldn't trust something from amazon to open a can of beans that was already open.
I'm certainly not going to put something from amazon in my body. God only knows what you're actually getting
When you buy from reliable brands with a wide range of supplements in their own store on Amazon, you get what that store offers on Amazon as well as elsewhere. If you don't know the brand, Amazon is a bad place to learn about them.
So is 10,000 IU of daily does ok ?
yes, but not long term, from what i’ve read. do it for 90 days through winter maybe?
What have you read?
TLDR Unfortunately, medicine took a very long time to realize that vitamin D is not simply a vitamin that prevents rickets.
We know today that vitamin D is a powerful nuclear receptor-activating hormone of critical importance, especially to the immune system.
With the available data mentioned above, the proposed doses would probably suffice to maintain vitamin D levels around or over 75-100 nmol/L, with practically zero risk of toxicity.
(2017)
Some previous discussions:
4 months ago, flagged: https://news.ycombinator.com/item?id=44705486
2020: https://news.ycombinator.com/item?id=24768721
2017: https://news.ycombinator.com/item?id=15867918
More recent Vitamin D discussions:
We're learning more about what Vitamin D does
https://news.ycombinator.com/item?id=46088998
Vitamin D reduces incidence and duration of colds in those with low levels
https://news.ycombinator.com/item?id=45732670
This article is very technical and difficult to read. Is there a TLDR?
Vitamin D good. Higher levels than previously thought.
Eat one small rock per day as important source of vitamins and minerals critical to digestive health.
This is why I eat fruity pebbles.
2, they must all build up and grind together in your crop before expulsion for proper results.
Wait, we're talking about birds right?
If poultry or pigeon, eat two per day.
The article's conclusion is straightforward.
Nicely uninformative, but technically correct.
This article is not technical and is 4 pages and includes a 1 paragraph executive summary. There's only 2 pages of content.
There's no specific info about any experiment. It just claims a statistics error was recently found in another paper/experiment. It claims fixing the error suggests we should supplement more Vitamin D.
It gestures vaguely at "Diabetes" and "immune health" and "we used to eat fish" to claim that we want/need more blood Vitamin D. It also points to some other actual studies that might have good evidence that we want or need more Vitamin D.
I would doubt anything in this could cause harm. Vitamin D is fat soluble so taking too much can be dangerous, but I don't think the recommended doses here are close to that dosage.
This paper aims for slightly more than 100nmol/l Vitamin D marker in blood, while other NIH papers claim >375nmol/l is getting into Vitamin D toxicity territory.
>https://pmc.ncbi.nlm.nih.gov/articles/PMC6158375/
NIH previously claimed a serum level of less than 72nmol/l is a health problem, so this paper is bumping that up slightly.
My understanding is that large scale tests of Vitamin D supplementation don't ever seem to turn out as great as all these papers would imply. Maybe their experiments had too low a dose.
My own supplementation has done jack and shit. Maybe I needed a higher dose.
I still hold skepticism that all of humanity needs a supplement, as that's just a sales pitch from a company at that point, but the "Everyone really does need a shitload of Vitamin D supplement" hypothesis at least has a mechanism that makes sense.
Do we need to be skeptical of NIH because of Trump? or they're still okay?
Also, remember - don't take D on its own. Always with magnesium, or you get harmed by it, for all that it also does you good. Body is not built for raw D.
Also also remember, D2 is a vitamin, D3 is a hormone.
> Also also remember, D2 is a vitamin, D3 is a hormone.
As a naive person, what's the consequence of this?
[flagged]
If you dry mushrooms in the sun they contain a crap-ton of D2.
If you're looking to build and maintain healthy vitamin D levels, D3 is generally the better supplement choice, according to health experts and studies. Consult your doctor to determine your needs and the best form for you, especially if you have a deficiency or dietary restrictions. -Google Gemini
I think it's important to clarify understandings for non-scientific/med community each time these types of technical discussions occur.
I don't think this paper is associated with the NIH besides being hosted there.
To be clear, NIH hosts an online database called PubMed that contains almost all published biomedical literature. If the article is open access, then it also hosts a copy of the article on PubMed Central.
This is the link to the article in the PubMed database: https://pubmed.ncbi.nlm.nih.gov/28768407/
You can click on the DOI link to go to the article hosted by the journal.
I mean, I agree MAHA sucks, and Kennedy is a fool and and loser, but the PDF is only hosted at the NIH. It was published in a journal owned by the Korean Society for Preventive Medicine, and the researcher is from Attikon University Hospital, University of Athens School of Medicine, Athens, Greece. And it was published WAAAAAAAY back in 2017.
So do your research or something.